Isoflurane at Subanesthetic Concentrations - 6

University of Chicago10 enrolled

Overview

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To test the hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water immersion pain in healthy volunteers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Interventions

40% Nitrous oxideDRUG

Used as pain assay positive control

Sham comparatorOTHER

0% isoflurane in oxygen

0.2% isofluraneDRUG

0.4% isoflurane

Eligibility

Sex: MALEMin age: 21 YearsMax age: 34 YearsHealthy volunteers:

Medical Language ↔ Plain English

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Locations (1)

University of Chicago, Anesthesia & Critical Care

Chicago, Illinois, United States

Outcomes

Primary Outcomes

Pain response

Effects of inhaled isoflurane on pain from immersion of subject's arm in ice cold water. Nitrous oxide (40%) was used as a positive control to confirm sensitivity of the pain assay.

Time frame: Post inhalation

Data from ClinicalTrials.gov

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