The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To examine sevoflurane versus isoflurane inhalation at subanesthetic concentrations on mood, pain, and psychomotor performance.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Masking
DOUBLE
Enrollment
12
University of Chicago, Anesthesia & Critical Care
Chicago, Illinois, United States
Pain intensity
Subjects underwent a 3 min cold immersion test at 30 min of inhalation and then provided response to pain intensity questionnaire
Time frame: 30 min of inhalation
Psychomotor performance
Subjects underwent psychomotor testing at baseline, during inhalation, and during recovery post inhalation
Time frame: Baseline, 5 min of inhalation; 5, 30, 60 minutes recovery
Cognitive performance
Subject underwent memory, sedation, visual analog, and drug effects testing
Time frame: Baseline, every 5 min during inhalation, 5, 30, & 60 min during recovery
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