A Laboratory Model for Heroin Abuse Medications - 8

New York State Psychiatric Institute8 enrolled

Overview

The purpose of this study is to evaluate the effects of treatment medications (methadone, buprenorphine, LAAM, naltrexone, naltrexone microcapsules, and methoclocinnamox) on I.V. and smoked heroin self-administration."

Abuse of prescription opioid medications has increased dramatically in the U.S. during the past decade, as indicated by a variety of epidemiological sources. However, few studies have systematically examined the relative reinforcing effects of commonly abused opioid medications. The current inpatient study was designed to compare the effects of intravenously delivered fentanyl , oxycodone, morphine, buprenorphine and heroin in morphine-maintained heroin abusers. All of the participants received all of the drugs tested; drugs and doses were administered in non-systematic order.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Heroin Dependence Opioid-Related Disorders Substance-Related Disorders

Interventions

opiatesDRUG

prescription opioids

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criterion 1. DSM IV criteria for opioid dependence 2. No major mood, psychotic, or anxiety disorder 3. Physically healthy 4. Able to perform study procedures 5. 21-45 years of age 6. Current use of i.v. heroin in amounts/frequencies 7. Not seeking treatment for opioid dependence Exclusion Criterion 1. DSM IV criteria for dependence on drugs other 2. Participants requesting treatment 3. Participants on parole or probation 4. Pregnancy or lactation 5. Birth, miscarriage or abortion with 6 months 6. Recent history of or current significant violent behavior 7. Current major Axis I psychopathology, other than heroin dependence ( e.g., mood disorder with functional impairment or suicide risk, schizophrenia), which might interfere with ability to participate in the study 8. Hepatitis with SGOT or SGPT \> 3 times normal 9. Significant suicide risk 10. Current or history of chronic pain 11. Sensitivity, allergy, or contraindication to opioids

Locations (2)

Columbia University

New York, New York, United States

New York State Psychiatric Institute

New York, New York, United States

Outcomes

Primary Outcomes

Amount drug self-administered

All of the participants received all of the drugs tested; drugs and doses were administered in non-systematic order. Participants were instructed to choose between the dose that they had received during the sample session or another reward..

Time frame: 90 minutes

Secondary Outcomes

Subjective responses

Four questionnaires were used to assess subjective effects

Time frame: 90 min

Data from ClinicalTrials.gov

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