Pemoline in the Treatment of Stimulant Dependence - 5

National Institute on Drug Abuse (NIDA)

Overview

The purpose of this study is to assess the efficacy of pemoline in treating cocaine and/or methamphetamine dependent adults with comorbid Adult Attention Deficit Hyperactivity Disorder (ADHD).

Study Type

INTERVENTIONAL

Purpose

TREATMENT

Conditions

Cocaine-Related Disorders

Interventions

PemolineDRUG

Eligibility

Sex: ALLMin age: 21 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: M/F ages 21-50. Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the study and sign informed consent. Exclusion Criteria: Psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nuring women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics. Acute hepatitis. Other medical condtions that deem participation to be unsafe.

Outcomes

Primary Outcomes

Retention

Depression

Incidence of stimulant use

Severity of stimulant withdrawal symptoms

ADHD symptom severity

Degree of drug craving

Frequency of IV drug use and sexual risk behaviors

Data from ClinicalTrials.gov

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