Behavior and Naltrexone Treatment for Alcoholics

National Institute on Alcohol Abuse and Alcoholism (NIAAA)160 enrolled

Overview

The study's purpose is to improve alcoholism treatment by investigating the combined effectiveness of a psychotherapy (Coping Skills Training and Cue Exposure Treatment - CSTCET) with naltrexone in a randomized clinical trial. Individuals will receive 2 weeks of CSTCET or a control treatment as inpatients followed by 12 consecutive weeks of receiving either naltrexone or placebo as outpatients. Followups at 24, 48, and 72 weeks after treatment is completed.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Enrollment

160

Conditions

Alcoholism

Interventions

naltrexone (Revia)DRUG

cognitive behavioral therapyBEHAVIORAL

cue exposure treatmentBEHAVIORAL

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Meets criteria for alcohol dependence. Exclusion Criteria: * Current diagnosis of dependence on other substances except nicotine. * A history of psychosis or current psychotic symptoms. * Current suicidality, homocidality, or psychiatric symptoms that require additional medication. * Current use of disulfiram (Antabuse). * Evidence of significant cerebral, renal, thyroid, or cardiac disease. * History of opioid abuse in the previous year. * History of cirrhosis, hepatocellular disease, or elevated bilirubin. * Females who are pregnant, nursing, or not using a reliable method of birth control.

Locations (1)

Brown University, Center for Alcohol and Addiction Studies

Providence, Rhode Island, United States

Data from ClinicalTrials.gov

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