Naltrexone Maintenance Treatment of Alcoholism

Inclusion Criteria: * Meets criteria for alcohol dependence. * Expresses a desire to cut down or stop drinking. Exclusion Criteria: * Currently meets criteria for dependence on substances other than alcohol. * History of opiate dependence or evidence of current opiate use. * Significant medical disorders that will increase potential risk or interfere with study participation. * Liver function tests more than 3 times normal or elevated bilirubin. * Female patients who are pregnant, nursing, or not using a reliable method of birth control. * Inability to understand and provide a consent form. * Treatment with an investigational drug during the previous month. * Prior treatment with naltrexone. * Chronic treatment with any narcotic-containing medications during the previous month. * Sensitivity to naltrexone as evidenced by adverse drug experiences especially with narcotic containing analgesics or opioid antagonists. * Current treatment with disulfiram. * More than 6 weeks of abstinence. * Meets criteria for a major psychiatric disorder and is in need of, or currently undergoing pharmacotherapy.