Naltrexone Treatment of Alcohol Dependence

Inclusion Criteria: * Meets criteria for current diagnosis of alcohol dependence. * Subjects used more than 15 standard alcohol drinks (average)/week with at least 1 day of 5 or more drinks in the past 30 days. * Successful completion of medical detoxification. * Lives within a commutable distance to the Treatment Research Center and agrees to follow-up visits. * Understands and signs the informed consent. Exclusion Criteria: * Current diagnosis of any substance dependence other than alcohol, nicotine, or marijuana. * Evidence of opiate use in the past 30 days. * Current treatment with psychotropic medications, including disulfiram (Antabuse) (excluding short-term use of benzodiazepines for detoxification). * History of unstable or serious medical illness, including need for opioid analgesics. * Severe physical or medical illnesses such as AIDS, active hepatitis, significant hepatocellular injury as evidenced by elevated bilirubin levels, and current severe psychiatric symptoms. * Use of an investigation medication in the past 30 days. * Female subjects who are pregnant, nursing, or not using reliable method of contraception.