Pharmacologic Relapse Prevention for Alcoholic Smokers

Inclusion Criteria: * History of alcohol dependence and at least one year of abstinence from alcohol intake. * Has a history of smoking 20 or more cigarettes per day for the prior year. * Can read and write English. * Stated ability to fully participate in the study and keep all scheduled appointments. * Has provided written informed consent. * General good health. Exclusion Criteria: * Recent history (within three months) of a clinically significant myocardial infarction, unstable angina pectoris, serious cardiac arrhythmia or any other medical condition which the physician investigator deems incompatible with study participation. * Current major depression. A past history of major depression will not be an exclusionary criteria. * Current or previous use of bupropion (Wellbutrin). * Active non- nicotine drug dependence. * Past or current history of bipolar disorder, pain disorder or psychosis, schizophrenia, or other major psychiatric disorders. * Current medically indicated use of psychiatric drugs. * Females who are pregnant, lactating, or likely to become pregnant during the first year which includes the nicotine patch and bupropion (Wellbutrin) phase. * History of severe skin allergies or evidence of severe chronic skin disorders. * Current use of nicotine containing medication or tobacco products other than cigarettes. * Current use (within 30 days of initiation of patch therapy) of the following medications for smoking cessation: clonidine, buspirone, or doxepin. * A predisposition to seizures. * A history of or current diagnosis of anorexia nervosa or bulimia. * Medical disorder that would interfere with the absorption, metabolism, or excretion of bupropion (Wellbutrin).