Pharmacokinetics of Nystatin LF I.V. in Patients With Acquired Immune Deficiency Syndrome-Related Complex (ARC)

Inclusion Criteria Patients must have the following: * Positive HIV antibody test. * Diagnosis of AIDS-related complex (ARC). * CD4+ cell count between 100 and 300 cells/mm3. * Estimated life expectancy of at least 6 months. * Normal neurological status. Exclusion Criteria Co-existing Condition: Patients with the following conditions or symptoms are excluded: * Active opportunistic infection requiring ongoing therapy except patients being treated topically for oral thrush. Patients with the following are excluded: * Active opportunistic infection. * Known hypersensitivity to polyene antibiotics. * Unwillingness to sign an informed consent or to be in compliance of protocol requirements. Prior Medication: Excluded within 72 hours of study entry: * Biologic response modifier agents. * Corticosteroids. * Cytotoxic chemotherapeutic agents. * Potential nephrotoxins. * Potential neutropenic agents. * Rifampin or rifampin derivatives. * Systemic anti-infectives. * Phenytoin or barbiturates (inducers of microsomal enzymes). * All systemic medications. Prior Treatment: Excluded within 72 hours prior to study entry: * Radiation therapy. Active alcohol or drug abuse unless they have been off drugs and/or alcohol for two weeks prior to start of study.