Treatment and Suppression of Hairy Leukoplakia in ARC Patients With Oral Acyclovir (ACV)

Inclusion Criteria Concurrent Medication: Allowed: * Topical antifungal therapy. Patient must have: * Newly diagnosed clinical and histological hairy leukoplakia. * Positive HIV antibody by licensed ELISA or Western blot. Exclusion Criteria Co-existing Condition: Patients with AIDS or a history of intolerance or allergy to acyclovir are excluded. Concurrent Medication: Excluded within 2 weeks of study entry: * Systemic antifungal treatment. * Excluded within 6 weeks of study entry: * Immunomodulators. * Systemic antiviral treatment. Patients with AIDS or a history of intolerance or allergy to acyclovir are excluded. Prior Medication: Excluded within 2 weeks of study entry: * Systemic antifungal. * Excluded within 6 weeks of study entry: * Immunomodulators. * Systemic antiviral treatment. * Excluded within 8 weeks of study entry: * Zidovudine (AZT) or other antiretroviral therapy.