An Open Study of Foscarnet Treatment First Episode CMV-Retinitis in AIDS Patients

Exclusion Criteria Co-existing Condition: Patients with the following are excluded: * Any clinically significant pulmonary or neurologic impairment (e.g., patients who are intubated or comatose). * Corneal, lens, or vitreous opacification which precludes examination of the fundi, or evidence of tuberculotic, diabetic and/or hypertensive retinopathy. * Known allergy to foscarnet. * Recurrent episode of cytomegalovirus (CMV) retinitis. Concurrent Medication: Excluded: * Nephrotoxic drugs. Patients with the following are excluded: * Recurrent episode of cytomegalovirus (CMV) retinitis. * Any clinically significant pulmonary or neurologic impairment (e.g., patients who are intubated or comatose). * Corneal, lens, or vitreous opacification which precludes examination of the fundi, or evidence of tuberculotic, diabetic, and/or hypertensive retinopathy. * Known allergy to foscarnet. Prior Medication: Excluded: * Ganciclovir for cytomegalovirus (CMV) retinitis. * Foscarnet for CMV retinitis. Patients with AIDS as defined by the CDC with manifest first episode cytomegalovirus (CMV) retinitis, as identified by its characteristic ophthalmoscopic appearance and verified by fundus photography. * Patients must be able to give informed consent.