A Double-Blind Placebo Controlled Study To Determine the Optimal Immunopharmacological Dose Level of Isoprinosine in Immunodepressed Volunteers

Exclusion Criteria Co-existing Condition: Patients with the following are excluded: * Opportunistic infections or Kaposi's sarcoma. * Critical illness. * History of gout, urolithiasis, nephrolithiasis, renal dysfunction, and severe gastric ulcer. Concurrent Medication: Excluded: * Steroids. * Cytotoxic immunosuppressive agents. Concurrent Treatment: Excluded: * Radiotherapy. The following are excluded: * Opportunistic infections or Kaposi's sarcoma. * Critically ill patients. * Patients receiving steroids, cytotoxic immunosuppressive agents, and/or radiotherapy. * Patients who have received any other immunotherapy. * Patients with a history of gout, urolithiasis, nephrolithiasis, renal dysfunction, and severe gastric ulcer. Prior Medication: Excluded: * Any other immunotherapy. Patients who fall into the group which is at risk of developing cutaneous sarcoma and/or opportunistic diseases but at present have no signs or symptoms of these diseases.