A Multi-Center Randomized Double-Blind Placebo-Controlled Study To Investigate the Effect of Isoprinosine in Immunodepressed Patients With Uncomplicated Generalized Lymphadenopathy

Exclusion Criteria Co-existing Condition: Patients with the following are excluded: * History of gout, uric acid urolithiasis, uric acid nephrolithiasis, renal dysfunction, and severe gastric ulcer. * Lymphoid malignancy. * Infectious mononucleosis caused by cytomegalovirus (CMV) or Epstein-Barr virus (EBV). * Heart disease (especially if receiving cardiac glycosides). * Hemophilia. Patients with the following are excluded: * Kaposi's sarcoma or overt opportunistic infections. * Active evidence of infectious mononucleosis caused by Epstein-Barr virus (EBV) or cytomegalovirus (CMV) as determined by heterophile test (EBV) or cell culture (CMV). * A history of gout, uric acid urolithiasis, uric acid nephrolithiasis, renal dysfunction, and severe gastric ulcer. * Critical illness. * Condition requiring hospitalization. * Women of childbearing age are excluded. Prior Medication: Excluded: * Steroids, cytotoxic immunosuppressive agents. * Antiviral medicine. * Excluded within 1 month of study entry: * Immunomodulators (including Isoprinosine). Prior Treatment: Excluded: * Radiotherapy. Patients who have unexplained immunodepression and are at risk of developing AIDS. * Patients with prolonged generalized lymphadenopathy for 3 or more months (greater than 1 cm at two or more noncontiguous sites). IV drug abuse.