A Comparative Trial of Valacyclovir Hydrochloride ( 256U87 ) and Acyclovir for the Suppression of Anogenital Herpes Infections in HIV-Infected Patients

Inclusion Criteria Patients must have: * HIV infection with CD4 counts = or \> 100 cells/mm3. * Documented culture of anogenital herpes simplex virus (HSV) within the last 5 years. * History of recurrent anogenital HSV infection, with a recurrence (with or without culture) within 1 year prior to study. Exclusion Criteria Co-existing Condition: Patients with the following symptoms and conditions are excluded: * Malabsorption or vomiting that would potentially limit the retention and absorption of oral therapy. Concurrent Medication: Excluded: * Systemic antiherpes medication. * Interferon. Patients with the following prior conditions are excluded: History of hypersensitivity to acyclovir.