Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Bleomycin and Vincristine in the Treatment of AIDS-Related Kaposi's Sarcoma

Inclusion Criteria Concurrent Medication: Allowed: * Prophylaxis for PCP, cryptococcal, and herpes infections, and antiretroviral therapy (e.g., AZT, ddC, ddI) provided these doses have been stable for at least 1 month. * Maintenance therapy for tuberculosis, fungal, and herpes infections. * Therapy for new episodes of tuberculosis, fungal, and herpes infection except with potentially myelotoxic chemotherapy. * Foscarnet for cytomegalovirus infection. * Erythropoietin. Patients must have: * Biopsy-proven, progressive, AIDS-related Kaposi's sarcoma, with any of the following: * At least 15 mucocutaneous lesions. * Six or more new lesions in the prior month. * Documented visceral disease with at least five accessible cutaneous lesions. * Documented anti-HIV antibody. * No active opportunistic infection with mycobacteria, cytomegalovirus, toxoplasma, Pneumocystis carinii, or other microorganisms (if REQUIRING treatment with myelotoxic drugs). * Life expectancy \> 4 months. NOTE: * Patients who fail the BV combination or who relapse are eligible to enter the Liposome Technology open trial using DOX-SL alone. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: * Clinically significant cardiac disease. * Confusion, disorientation, CNS symptoms, or peripheral neuropathy. Concurrent Medication: Excluded: * Other cytotoxic chemotherapy. * Colony-stimulating factors. * Ganciclovir. Patients with the following prior conditions are excluded: * Prior neoplasms treated with extensive chemotherapy that, in the investigator's opinion, has led to irreversibly compromised bone marrow function. * History of idiosyncratic or allergic reaction to anthracyclines, bleomycin, or vincristine. * History of major psychiatric illness. Prior Medication: Excluded: * Cytotoxic chemotherapy or interferon therapy within the past 4 weeks. * More than one prior cycle of bleomycin/vincristine at any time. Prior Treatment: Excluded: * Radiation or electron beam therapy within the past 3 weeks.