Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea

Inclusion Criteria Patients must have: * ARC or AIDS by CDC criteria. * Uncontrolled diarrhea unresponsive to high-dose, nonspecific antidiarrheal therapy. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: * Known idiopathic ulcerative colitis or Crohn colitis. * Acute stool-culture-positive bacterial colitis. * Acute amoebic colitis. * Pseudomembranous colitis with Clostridium difficile toxin positivity. * Short-gut syndrome. * Chronic pancreatitis. * Ischemic bowel disease. * Enteroenteric fistulae. * Other gastrointestinal tract disorders known to cause diarrhea. * Underlying evidence of immunosuppression other than that related to HIV infection. * Unable or unwilling to have subcutaneous injections. * Clinically significant CNS, hepatic, or renal disease. Concurrent Medication: Excluded: * Other experimental antidiarrheal drugs. * Antibiotic therapy. Prior Medication: Excluded: * Other experimental drugs within 1 month prior to study entry. Required: * At least 2 weeks of prior high-dose, nonspecific antidiarrheal therapy (i.e., loperamide, diphenoxylate hydrochloride-atropine sulfate, or opiates) at maximally tolerable doses.