To determine the objective tumor response and remission rate of AIDS-related Kaposi's sarcomas (KS) following a single dose of tin ethyl etiopurpurin (SnET2) followed by photodynamic therapy (PDT). To determine the systemic and local toxicity, and morbidity safety profile of SnET2-PDT.
All patients receive a single dose of SnET2 and are randomized to receive either PDT light treatment or no light treatment (control group). Patients are assessed prior to and at 4, 12 and 24 weeks following treatment, and are followed for 7 months.
Study Type
INTERVENTIONAL
Purpose
TREATMENT
Enrollment
78
Univ of Southern California / Los Angeles
Los Angeles, California, United States
Cedars Sinai Med Ctr
Los Angeles, California, United States
Univ of California / San Francisco / Dermatology
San Francisco, California, United States
Health One - Rocky Mountain Cancer Ctr
Denver, Colorado, United States
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Buffalo Gen Hosp / PDT Ctr
Buffalo, New York, United States
Thompson Cancer Survival Ctr
Knoxville, Tennessee, United States