A Phase II, Stratified, Randomized, Double-Blind, Multi-Center Study of the Safety and Efficacy of Adefovir Dipivoxil (ADF) at Two Dose Levels in Triple Combination Therapies With Protease Inhibitors (PI) and Nucleoside Reverse Transcriptase Inhibitors (RTI) for the Treatment of HIV-Infected Patient

Inclusion Criteria Patients must have: * Laboratory diagnosis of HIV infection (positive HIV antibody test confirmed by Western blot, p24 antigen assay, HIV-1 RNA, or HIV-1 culture). * An HIV-1 RNA plasma titer \>= 5000 copies/ml within 14-21 days prior to the baseline visit. * CD4 cell count \>= 100 cells/mm3 within 14-21 days prior to the baseline visit. * A minimum life expectancy of at least 1 year. * Signed, informed consent from parent or legal guardian for those patients \< 18 years of age. Exclusion Criteria Co-existing Condition: Patients with any of the following symptoms and conditions are excluded: * Active, serious infections (other than HIV infection) requiring parenteral antibiotic or antiviral therapy. Patients will be considered recovered from such infectious episodes if at least 2 weeks elapsed following the cessation of parenteral therapy before the baseline visit. * Exhibiting evidence of a gastrointestinal malabsorption syndrome or chronic nausea or vomiting that may confer an inability to receive an orally administered medication. * Malignancy other than cutaneous Kaposi's sarcoma (KS) or basal cell carcinoma. Patients with biopsy-confirmed cutaneous KS are eligible, but must not have received any systemic therapy for KS within 4 weeks prior to baseline and are not anticipated to require systemic therapy during the study. * Any other clinical condition that in the opinion of the investigator would make the patient unsuitable for study or unable to comply with the dosing requirements. Patients with any of the following prior conditions are excluded: * A new AIDS-defining event diagnosed within 1 month prior to baseline. * Significant history of peripheral neuropathy. 1\. Treatment with immunomodulating agents such as systemic corticosteroids, IL-2, or interferons. * Ritonavir, indinavir, nevirapine, delavirdine, didanosine, dideoxycytidine, interferon alpha, interferon beta, isoniazid, rifampin, investigational agents (except upon Sponsor approval), chemotherapeutic agents (systemic), terfenadine, astemizole, cisapride, triazolam, and midazolam. 1\. Prior use of adefovir dipivoxil. * Prior use of any antiretroviral protease inhibitor. * Immunizations within 30 days of baseline. * Antiretroviral vaccine therapy within 60 days of baseline. * Treatment in the 4 weeks prior to baseline with immunomodulating agents such as systemic corticosteroids, IL-2, or interferons. * Any other investigational drug within 30 days prior to baseline. * Any prior therapy that, in the opinion of the investigator, would make the patient unsuitable for study or unable to comply with the dosing requirements. Required: Prior therapy for \> 4 weeks with any licensed nucleoside analog inhibitor of HIV reverse transcriptase. Patients with current alcohol or substance abuse judged by the investigator to potentially interfere with patient compliance.