A Study of ISIS 2922 in the Treatment of Advanced Cytomegalovirus Retinitis

Inclusion Criteria Concurrent Medication: Allowed: * Oral ganciclovir. * Leukocyte growth factors (GM-CSF and G-CSF) for patients with febrile neutropenia. Patients must have: * Documented AIDS. * Clinical diagnosis of advanced CMV retinitis in 1 or both eyes. * \>= 2 previous induction courses with anti-CMV retinitis therapy licensed by a regulatory agency. * \> 25% retinal involvement with CMV retinitis. * Baseline CMV retinitis lesions which have leading edges \> 1000 micrograms from the macula or optic disk. Prior Medication: Required: * \>= 2 previous induction courses with anti-CMV retinitis therapy licensed by a regulatory agency. Allowed: * All anti-CMV therapies other than ganciclovir must be discontinued no less than 2 days prior to entry. Exclusion Criteria Co-existing Condition: Patients with the following symptoms and conditions are excluded: * External ocular infection in the eye to be treated. * Other herpetic infections of the retina, toxoplasma, retinochoroiditis, or other disease of the fundus that would preclude assessment of CMV retinitis in the eye to be treated. * Ocular conditions that will obstruct visualization of the posterior ocular structures on the eye to be treated. * Retinal detachment in the eye to be treated. * Ganciclovir implant in the eye to be treated. * Known or suspected allergy to phosphorothioate oligonucleotides or intolerance of ISIS 2922. * Silicone oil in the eye to be treated. * Pseudoretinitis pigmentosa. * Syphilis. Patients with the following prior conditions are excluded: * History of surgery to correct retinal detachment in the eye to be treated. * History of syphilis. 1\. Systemic anti-CMV therapies other than oral ganciclovir. * Mellaril, Stelazine, chlorpromazine and clofazimine. * Combination use of ethambutol and fluconazole. * Investigational medications and/or procedures for the treatment of CMV retinitis in the eye to be treated. * Ganciclovir implant delivery device in the eye to be treated. * Ganciclovir other than oral. * Foscarnet.