A Study of 1592U89 and Ethanol When Given Together to HIV-Infected Patients

Inclusion Criteria Concurrent Medication: Allowed: * Local treatment for Kaposi's sarcoma. * Prophylactic treatment for opportunistic infections. Patients must have: * HIV-1 infection. * CD4+ lymphocyte count \>= 200 cells/microliter within 14 days prior to study drug administration. * No active diagnosis of AIDS (other than visceral Kaposi's sarcoma) according to the 1993 Centers for Disease Control and Prevention (CDC) AIDS surveillance definition. Prior Medication: Allowed: Local treatment for Kaposi's sarcoma. Exclusion Criteria Co-existing Condition: Patients with the following symptoms and conditions are excluded: Malabsorption syndrome or other GI dysfunction which may interfere with drug absorption. Concurrent Medication: Excluded: * Medications that cannot be withheld for 48 hours (24 hours for antiretrovirals) prior to study drug administration and until 12 hours after study drug administration on each dosing day. * Immunomodulators, such as systemic corticosteroids, interleukins and interferons. * Cytotoxic chemotherapeutic agents. * Acute treatment for opportunistic infections. Concurrent Treatment: Excluded: Radiation therapy. Patients with the following prior conditions are excluded: * Documented history of alcoholism. * History of clinically relevant hepatitis or pancreatitis within 6 months prior to study drug administration. * History of hypersensitivity, anaphylactic, or idiosyncratic reaction to nucleoside analogs. * Participation in another research study within the past month. Prior Medication: Excluded: * Cytotoxic chemotherapeutic agents within six weeks prior to study drug administration. * Immunomodulating agents within six weeks prior to study drug administration. * Treatment with the following within 2 weeks prior to study drug administration: * acyclovir, carbamazepine, chloramphenicol, ganciclovir, phenytoin, rifampin, sodium valproate, or valacyclovir. Prior Treatment: Excluded: Radiation therapy within 6 weeks prior to study drug administration. 1\. Regular weekly alcohol intake of more than 21 units (a unit is equal to 1/2 pint beer or 1 glass of wine or 1 oz of liquor). * Recent change in normal pattern of alcohol usage (e.g., prolonged use followed by \> one month abstinence). * Total abstinence from alcohol use. * Positive breath alcohol test upon arrival at the study center prior to any dosing day.