Safety and Effects of Giving a New HIV Vaccine (GENEVAX-HIV) to HIV-Negative Volunteers

Inclusion Criteria You may be eligible for this study if you: * Are 18 - 60 years old. * Are HIV-negative and in good health. * Are able to understand how infections such as HIV are spread. * Agree to use effective methods of birth control during the study. Exclusion Criteria You will not be eligible for this study if you: * Have hepatitis B or C. * Have any condition that may prevent you from completing the study. * Are allergic to bupivacaine, vaccines, or certain local anesthetics. * Have taken certain medications or have received certain therapies that may affect your immune system. * Have an immune system disorder or have received therapy for an immune system disorder. * Have been exposed to HIV within 6 months prior to study entry. * Have received an experimental HIV vaccine or any other experimental treatment within 30 days prior to study entry. * Have received blood transfusions within 6 months prior to study entry. * Abuse alcohol or drugs or have an uncontrolled psychiatric disorder. * Are pregnant or breast-feeding.