Phase II Study of Intravenous Novantrone(R) in the Treatment of AIDS Related Kaposi's Sarcoma

Inclusion Criteria Patients must have the following: * Biopsy proven Kaposi's sarcoma in advanced stages. * Positive HIV antibody, HIV culture or antigen capture or T4 cells \< 500 in a patient with AIDS risk factor. * Informed consent and availability for follow-up. Exclusion Criteria Co-existing Condition: Patients with the following conditions or symptoms are excluded: * Uncontrolled opportunistic infection. * Any medical, surgical or psychiatric condition which would constitute a contraindication to the use of mitoxantrone. Concurrent Medication: Excluded: * Zidovudine (AZT). Patients with the following are excluded: * Uncontrolled opportunistic infection. * Unable to give informed consent. * Any medical, surgical or psychiatric condition which would constitute a contraindication to the use of mitoxantrone. Prior Medication: Excluded: * More than one form of chemotherapy regimen. * Doxorubicin therapy \> 300 mg/m2. Prior Treatment: Excluded: * Previous therapy consisting of more than one modality of therapy (e.g., chemotherapy plus radiotherapy or more than one form of chemotherapy regimen.)