The Effects of AZT and Ibuprofen on HIV-Infected Patients With Hemophilia

University of Pittsburgh

Overview

To determine if platelet dysfunction and/or pharmacologic drug interaction occurs in patients taking both AZT and ibuprofen, which might account for enhanced bleeding tendency.

Study Type

INTERVENTIONAL

Purpose

TREATMENT

Conditions

HIV Infections Hemophilia A

Interventions

IbuprofenDRUG

ZidovudineDRUG

Eligibility

Sex: ALLMin age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria Patients must have: * Hemophilia. * HIV-seropositivity confirmed by Western Blot. Prior Medication: Required: \- AZT for study patients. Allowed: \- Ibuprofen. Exclusion Criteria Co-existing Condition: Patients with the following symptoms and conditions are excluded: Hospitalization for opportunistic infection, bacterial infection or malignancy. Concurrent Medication: Excluded: * AZT (for control group). * Antibiotics or other medication for opportunistic infection, bacterial infection, or malignancy. Patients with the following prior conditions are excluded: Hospitalization for opportunistic infection, bacterial infection, or malignancy. Required: * Ibuprofen. * AZT 1-2 gm daily (for study patient) or not taking AZT (for control).

Locations (1)

Hemophilia Ctr of Western PA / Univ of Pittsburgh

Pittsburgh, Pennsylvania, United States

Data from ClinicalTrials.gov

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