A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections

Inclusion Criteria Concurrent Medication: Allowed: * Immunostimulants under studies carried out under an IRB approved protocol. * Treatments of intercurrent non-fungal infection. * Allowed but requires monitoring during fluconazole therapy: * Barbiturates. * Phenytoin. * Oral hypoglycemics. * Coumarin-type anticoagulants. Patients must have the following: * Diagnosis or presumption of fungal infection under defined conditions. * Written informed consent either from the patient or the patient's legal guardian. Exclusion Criteria Co-existing Condition: Patients with the following conditions or symptoms are excluded: * Burns \> 30 percent of the body. * Diagnosis of AIDS or AIDS related complex (ARC). * HIV positive unless they have a malignancy. * History of allergy to or intolerance of imidazoles or azoles. * Moderate to severe liver disease as defined by specific lab values. * Unlikely to survive more than 24 hours. * Evidence of previous amphotericin B sensitivity. Concurrent Medication: Excluded: * Concomitant antifungal agents other than the study drugs. * Immunostimulants, except for studies carried out under an IRB approved protocol. Concurrent Treatment: Excluded: * Lymphocyte replacements. Patients with the following are excluded: * Defined disease conditions listed in Exclusion Co-Existing Conditions. * Unlikely to survive more than 24 hours. * Previous participation in this study; reentry for the same infection is not allowed. * Known to be unable to take amphotericin B due to acute toxicities. Prior Medication: Excluded: * Previous fluconazole therapy for this infection.