A Comparison of DOX-SL Versus Adriamycin Plus Bleomycin Plus Vincristine in the Treatment of Severe AIDS-Related Kaposi's Sarcoma

Inclusion Criteria Concurrent Medication: Allowed: * Prophylaxis for PCP, cryptococcal, and herpes infections, and antiretroviral therapy (e.g., AZT, ddC, ddI) provided these doses have been stable for at least 1 month. * Therapy for tuberculosis, fungal, and herpes infections except with potentially myelotoxic chemotherapy. * Foscarnet for new episodes of cytomegalovirus infection. * Colony-stimulating factors and erythropoietin. Patients must have: * Biopsy-proven, progressive, AIDS-related Kaposi's sarcoma, with any of the following: * At least 25 mucocutaneous lesions. * Ten or more new lesions in the prior month. * Documented visceral disease with at least two accessible cutaneous lesions. * Two accessible cutaneous lesions with edema. * Documented anti-HIV antibody. * No active opportunistic infection with mycobacteria, cytomegalovirus, toxoplasma, Pneumocystis carinii, or other microorganisms (if under treatment with myelotoxic drugs). * Life expectancy \> 4 months. NOTE: * Patients who respond to therapy on this protocol, as well as those who fail the ABV combination, are eligible to enter the Liposome Technology open trial using DOX-SL alone. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: * Clinically significant cardiac, hepatic, or renal disease. * Peripheral neuropathy, signs of moderate to severe sensory loss, or moderate to marked motor loss. * Inability to comply with the study. Concurrent Medication: Excluded: * Other cytotoxic chemotherapy. * Ganciclovir. Patients with the following prior conditions are excluded: * Prior neoplasms treated with extensive chemotherapy that, in the investigator's opinion, has led to irreversibly compromised bone marrow function. * History of idiosyncratic or allergic reaction to bleomycin or vincristine. Prior Medication: Excluded: * Prior anthracycline therapy. * Cytotoxic chemotherapy or interferon treatment within the past 4 weeks. Prior Treatment: Excluded: * Radiation or electron beam therapy within the past 3 weeks.