A Study of Multiple Doses of Vesnarinone in Advanced HIV Disease

Inclusion Criteria Concurrent Medication: Allowed: * Chemoprophylaxis for Pneumocystis carinii, candida, mycobacteria, and other opportunistic infections. * Acyclovir for up to 14 days for acute herpes outbreaks. Patients must have: * Documented HIV infection. * CD4 count 50 - 300 cells/mm3. * No active opportunistic infections. * No fever, diarrhea, or Herpes zoster. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: * Clinically significant current cardiac disease, including patients who exhibit long QTC syndrome on EKG screening and who have an abnormal cardiothoracic ratio on chest x-ray at baseline. * Active malignancy (other than cutaneous Kaposi's sarcoma or cutaneous basal cell carcinoma or in situ carcinoma of the cervix). Concurrent Medication: Excluded: * Antiretroviral agents, including ddI, ddC, AZT, and d4T. * Immunosuppressive agents. * Investigational HIV drugs/therapies including vaccines. * Interferon or other immunomodulating agents. * Corticosteroids (other than topical). * Hematopoietins. * Megestrol acetate. * Agents known to cause neutropenia. * Trimethoprim/sulfamethoxazole in excess of 160 mg trimethoprim and 800 mg sulfamethoxazole thrice weekly. * Cytotoxic chemotherapy. Concurrent Treatment: Excluded: * Radiation therapy. Patients with the following prior conditions are excluded: * Prior history of cardiac disease. * History of agranulocytosis or severe (grade 3 or worse) drug-induced neutropenia or documented abnormalities in granulocyte function. Prior Medication: Excluded: * AZT, ddI, ddC, d4T, or other nucleoside analog antiretroviral therapy within 14 days prior to study entry. * Prior cytotoxic chemotherapy. * Acyclovir for herpes prophylaxis within 48 hours prior to study entry. Prior Treatment: Excluded within 30 days prior to study entry: * Erythropoietin, transfusion, or blood product use. * Radiation therapy (including electron beam irradiation). Active use of illicit drugs (specifically cocaine, amyl nitrate, heroin, and other cardioactive agents).