A Study of Lobucavir in Patients With AIDS

Inclusion Criteria Concurrent Medication: Allowed: * Aerosolized pentamidine. * TMP / SMX. * Isoniazid. * Dapsone. * Fluconazole. * Ketoconazole. * Rifabutin. * Fluoxetine HCl. * Acetaminophen. * Antacids. * Metamucil. * Multivitamins. * Other drugs with approval from sponsor. Patients must have: * AIDS. * CD4 count \< 200 cells/mm3. * Cytomegalovirus ( CMV ) viruria and virosemenia. * No evidence of intraocular CMV. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: * Acute or chronic cardiovascular, pulmonary, renal, hepatic, pancreatic, hematologic, endocrine, neurological, or other unstable illness. * Inability to take oral medication. * Allergy to nucleoside analogs. * Diarrheal illness. * Poor venous access. * Positive test for drugs of abuse. * Any other condition that would render patient unsuitable for study. Patients with the following prior conditions are excluded: * History of pancreatitis. * Recent diarrheal illness. * History of weight loss. * Acute serious illness within 4 weeks prior to study entry. Prior Medication: Excluded within 4 weeks prior to study entry: * Erythropoietin. * Any agent with anti-CMV activity. * Other investigational agents. Prior Treatment: Excluded within 4 weeks prior to study entry: * Surgery. * Blood transfusion. Drug abuse.