A Comparison of ISIS 2922 Used Immediately or Later in Patients With Cytomegalovirus (CMV) of the Eyes

Inclusion Criteria Patients must have: * AIDS. * Clinical diagnosis of previously untreated peripheral CMV retinitis in one eye. * Leading edge of a CMV retinitis lesion is at least 750 microns from zone one. NOTE: * Patients with CMV retinitis in zone three only may be eligible if the lesions can be reliably photographed to follow progression. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions in the eye to be treated are excluded: * External ocular infections. * Other herpetic infections of the retina, toxoplasma retinochoroiditis, or other disease of the fundus. * Ocular conditions that will obstruct visualization of the posterior ocular structures. * Retinal detachment. * Silicone oil in eye. Patients with the following other symptoms or conditions are excluded: * Known or suspected allergy to phosphorothioate oligonucleotides. * Syphilis. * Pseudoretinitis pigmentosa. Concurrent Medication: Excluded: * Current treatment for extra-ocular CMV infection. * Ganciclovir. * Foscarnet. * Mellaril. * Stelazine. * Thorazine. * Clofazimine. * Ethambutol/fluconazole combination. * Investigational medications for CMV retinitis. Concurrent Treatment: Excluded: * Investigational procedures for CMV retinitis. Patients with the following prior conditions are excluded: * History of surgery to correct retinal detachment in the eye to be treated. * History of syphilis. Prior Medication: Excluded: * Prior anti-CMV retinitis treatment in either eye. * Anti-CMV therapy for extra-ocular infection within the past 2 days.