The Safety and Effectiveness of Lamivudine Plus Zidovudine, Used With and Without 1592U89, in HIV-1 Infected Patients Who Have Never Taken Anti-HIV Drugs

Inclusion Criteria Concurrent Medication: Allowed: * Local treatment for Kaposi's sarcoma. * Hematologic supportive therapy with GM-CSF, G-CSF, or erythropoietin. Patients must have: * HIV-1 infection as documented by a licensed HIV-1 antibody ELISA and confirmed by either Western blot detection of HIV-1 antibody or positive HIV-1 blood culture. * One screening CD4 lymphocyte cell count \>= 100 cells/mm3 within 14 days prior to study drug administration. * No active or ongoing AIDS-defining opportunistic infection or disease. * Signed, informed consent from parent or legal guardian for patients under 18 years of age. Exclusion Criteria Co-existing Condition: Patients with the following conditions and symptoms are excluded: * Malabsorption syndrome or other gastrointestinal dysfunction that might interfere with drug absorption or render the patient unable to take oral medication. * Serious medical conditions such as diabetes, congestive heart failure, cardiomyopathy, or other cardiac dysfunction, that, in the opinion of the investigator, would compromise the safety of the patient. Concurrent Medication: Excluded: * Foscarnet therapy. * Immunomodulating agents such as systemic corticosteroids, interleukins, thalidomide, anti-cytokine agents, or interferons. * Cytotoxic chemotherapeutic agents and antioxidants. Concurrent Treatment: Excluded: Radiation therapy. Patients with the following prior conditions are excluded: History of clinically relevant pancreatitis or hepatitis within the last 6 months. Prior Medication: Excluded: * Prior antiretroviral therapy. * Vaccination within the past 3 months given as part of an investigational HIV vaccine trial. * Chemotherapeutic agents within 30 days of study drug administration. * Immunomodulating agents such as systemic corticosteroids, interleukins or interferons, within 30 days of study drug administration. Prior Treatment: Excluded: Radiation therapy within 30 days of study period. Current alcohol or illicit drug use that, in the opinion of the investigator, may interfere with the patient's ability to comply with the dosing schedule and protocol evaluations.