The purpose of this study is to compare the safety and effectiveness of 2 dosing schedules (once daily vs twice daily) of lamivudine (3TC) given with stavudine (d4T) and either indinavir (IDV) or nelfinavir (NFV) for 24 weeks.
Patients are randomized to 1 of 2 groups. Group 1 receives 3TC qd plus d4T plus either IDV or NFV. Group 2 receives 3TC bid plus d4T plus either IDV or NFV. Patients are evaluated for drug tolerance, medication adherence, and genotypic and phenotypic resistance.
Study Type
INTERVENTIONAL
Purpose
TREATMENT
Masking
NONE
AIDS Healthcare Foundation
Los Angeles, California, United States
Palo Alto Veterans Affairs Health Care System
Palo Alto, California, United States
Dupont Circle Physicians Group
Washington D.C., District of Columbia, United States
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IDC Research Initiative
Altamonte Springs, Florida, United States
North Broward Hosp District
Fort Lauderdale, Florida, United States
Steinhart Medical Associates
Miami, Florida, United States
Northwestern Univ Med School
Chicago, Illinois, United States
Saint Vincents Hosp
New York, New York, United States
St Lukes - Roosevelt Hosp Ctr
New York, New York, United States
MCP Hahnemann Univ Hosp
Philadelphia, Pennsylvania, United States
...and 2 more locations