RATIONALE: Video-assisted surgery followed by radiation therapy may be an effective treatment in patients whose poor heart and lung function make them high risk for standard surgery. PURPOSE: Phase II trial to study the effectiveness of video-assisted surgery followed by radiation therapy in treating patients with stage I non-small cell lung cancer and poor heart and lung function.
OBJECTIVES: * Determine the feasibility of video-assisted thoracoscopic wedge resection (VAR) followed by radiotherapy in patients with stage I non-small cell lung cancer and cardiopulmonary dysfunction. * Determine the incidence of locoregional recurrence in patients treated with this regimen. * Determine the overall and disease-free survival in patients treated with this regimen. * Determine the technical feasibility of ipsilateral lymph node sampling and complete resection with VAR in these patients. * Determine the incidence of conversion to open thoracotomy in these patients. * Determine the short- and long-term complications associated with VAR in these patients. * Determine the toxicity of adjuvant radiotherapy after VAR in these patients. OUTLINE: This is a multicenter study. Patients undergo video-assisted thoracoscopic wedge resection. Surgeons attempt sampling and identification of all ipsilateral, mediastinal, and hilar lymph nodes. When accessible, lobar lymph nodes must also be sampled. If the tumor margins are positive, further resection of the margins must be attempted. Open thoracotomy may be required for technical reasons.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
66
CCOP - Colorado Cancer Research Program, Incorporated
Denver, Colorado, United States
John Stoddard Cancer Center at Iowa Methodist Medical Center
Des Moines, Iowa, United States
Determine the feasibility of video-assisted thoracoscopic wedge resection (VAR)
Time frame: Up to 10 years
Determine the incidence of locoregional recurrence in patients treated with this regimen
Time frame: Up to 10 years
Determine the overall and disease-free survival
Time frame: Up to 10 years
Determine the short- and long-term complications associated with VAR in these patients
Time frame: Up to 10 years
Determine the technical feasibility of ipsilateral lymph node sampling and complete resection with VAR in these patients
Time frame: Up to 10 years
Determine the toxicity of adjuvant radiotherapy after VAR in these patients
Time frame: Up to 10 years
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