Combination Chemotherapy Followed by Radiation Therapy in Patients With Small Cell Lung Cancer

Medical Research Council400 enrolled

Overview

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug is a way to kill more tumor cells. Combining radiation therapy with chemotherapy may kill more tumor cells. PURPOSE: Randomized phase III trial to compare the effect of two combination chemotherapy regimens followed by radiation therapy in treating patients with small cell lung cancer.

OBJECTIVES: * Compare the survival rate in patients with newly diagnosed small cell lung cancer and good performance status treated with an intensive regimen of ifosfamide/carboplatin/etoposide with mid-cycle vincristine (VICE) vs. standard chemotherapy followed, as feasible, by thoracic radiotherapy. * Compare the adverse effects of treatment and quality of life (including psychological distress, physical status, and functional status and global quality of life) in these patients. * Compare the Rotterdam Symptom Checklist vs. the EORTC QLQ-C30 and LC13 quality-of-life questionnaires in relation to compliance and ability to detect differences between treatments. OUTLINE: This is a randomized study. The first group receives standard combination chemotherapy with doxorubicin/cyclophosphamide/etoposide (ACE) or cisplatin/etoposide (PE) every 3 weeks for 6 courses. The second group receives intensive combination chemotherapy with carboplatin/ifosfamide/etoposide on days 1-3 with vincristine on day 14 (VICE). Courses repeat every 4 weeks for 6 courses. Patients in both groups are considered for thoracic radiotherapy beginning 4-5 weeks after the first day of the last course of chemotherapy. Concurrent prophylactic antibiotics should be given. Patients who relapse may receive further treatment at the clinician's option. Patients are followed monthly for 6 months, every 2 months for up to 1 year, every 3 months for up to 2 years, every 6 months for 5 years, and annually thereafter. PROJECTED ACCRUAL: A total of 400 patients will be entered over 3 years.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Enrollment

400

Conditions

Lung Cancer

Interventions

carboplatinDRUG

cisplatinDRUG

cyclophosphamideDRUG

doxorubicin hydrochlorideDRUG

Eligibility

Sex: ALL

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Microscopically proven small cell lung cancer * Diagnosis based on bronchial, mediastinal, pleural, lung, or lymph node biopsy, sputum cytology, or bronchial brushing or fine needle aspirate cytology * No pleural fluid cytology * No prior therapy PATIENT CHARACTERISTICS: Age: * Any age Performance status: * WHO 0-2 Hematopoietic: * WBC more than 3,000 * ANC more than 1,500 * Platelets more than 100,000 Hepatic/Renal: * Alkaline phosphatase, aminotransferase, sodium, and LDH normal or no more than 1 of them abnormal * Creatinine or urea normal * Creatinine clearance or GFR more than 65 mL/min Other: * No clinical evidence of infection * No prior or concurrent malignancy that interferes with protocol treatments or comparisons * No other condition that contraindicates treatment * Willing and able to complete quality-of-life questionnaires * Hospital Anxiety and Depression Scale, Rotterdam Symptom Checklist, and EORTC questionnaires completed prior to randomization PRIOR CONCURRENT THERAPY: Biologic therapy: * See Disease Characteristics Chemotherapy: * See Disease Characteristics Endocrine therapy: * See Disease Characteristics Radiotherapy: * See Disease Characteristics Surgery: * See Disease Characteristics

Locations (1)

Medical Research Council Clinical Trials Unit

London, England, United Kingdom

Data from ClinicalTrials.gov

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