RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with bone marrow transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of bone marrow transplantation in treating patients with chronic lymphocytic leukemia.
OBJECTIVES: Examine the potential role for high dose cyclophosphamide, total body irradiation and bone marrow transplantation for patients with chronic lymphocytic leukemia who are at high risk for disease progression. OUTLINE: Patients receive daily intravenous infusions of cyclophosphamide for two days, followed by total body irradiation in four daily exposures. After completion of the total body irradiation, allogeneic or autologous bone marrow is infused intravenously. PROJECTED ACCRUAL: 50 patients are expected to be accrued.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
49
Daily intravenous infusions of cyclophosphamide for two days,
After completion of the TBI, allogeneic or autologous bone marrow infused intravenously.
After completion of the TBI, allogeneic or autologous bone marrow infused intravenously.
University of Texas - MD Anderson Cancer Center
Houston, Texas, United States
Effectiveness of high dose cyclophosphamide, total body irradiation and bone marrow transplantation for chronic lymphocytic leukemia
Time frame: 1 year
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Following 2 days of cyclophosphamide, TBI in four daily exposures then bone marrow transplant.