RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase III trial to study the effectiveness of paclitaxel in treating older patients who have solid tumors.
OBJECTIVES: * Determine whether there is a relationship between pharmacokinetic measurements of paclitaxel and aging. * Determine whether there is a relationship between the toxic effects of paclitaxel and aging. OUTLINE: Patients are stratified according to age (cohort 1: patients 55 to 64 vs cohort 2: patients 65 to 75 vs cohort 3: patients 75 and over).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
120
Overall survival
Time frame: Up to 5 years
Disease-free progression
Time frame: Up to 5 years
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Rebecca and John Moores UCSD Cancer Center
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...and 22 more locations