Computer Planned Radiation Therapy in Treating Patients With Prostate Cancer

Memorial Sloan Kettering Cancer Center50 enrolled

Overview

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Computer systems that allow doctors to create a 3-dimensional picture of the tumor in order to plan treatment may result in more effective radiation therapy. PURPOSE: This phase II trial is studying how well radiation therapy that has been planned with a computer works in treating patients with prostate cancer.

OBJECTIVES: * Establish the efficacy of high-dose three-dimensional conformal radiotherapy in patients with intermediate prognostic risk adenocarcinoma of the prostate. * Determine the PSA relapse-free survival rate of this patient population. OUTLINE: Patients receive high-dose three-dimensional conformal radiotherapy 4-5 days per week for at least 9 weeks. Patients are evaluated at least weekly during radiotherapy and at 2 and 4 months after treatment completion. Thereafter, patients are followed every 6 months for a total of 3 years. PROJECTED ACCRUAL: A total of 50 patients will be accrued for this study.

Study Type

INTERVENTIONAL

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Prostate Cancer

Interventions

radiation therapyRADIATION

Eligibility

Sex: MALE

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Histologically proven intermediate prognostic risk (T1-T2) adenocarcinoma of the prostate * Previously untreated (except for hormonal therapy) * PSA levels greater than 10 ng/mL and Gleason scores no greater than 6 OR * PSA levels no greater than 10 ng/mL and Gleason scores at least 7 * Patients requiring volume reduction of prostate prior to radiotherapy continue to be treated at least 3 months on neoadjuvant hormonal therapy prior to radiation * No evidence of distant metastases * No regional lymph node involvement PATIENT CHARACTERISTICS: Age: * Not specified Performance status: * Not specified Life expectancy: * Not specified Hematopoietic: * Not specified Hepatic: * Not specified Renal: * Not specified Other: * No major medical illness * No psychosis * No metallic pelvic prosthesis PRIOR CONCURRENT THERAPY: Biologic therapy: * Not specified Chemotherapy: * No prior chemotherapy Endocrine therapy: * See Disease Characteristics * Prior neoadjuvant antiandrogen therapy allowed Radiotherapy: * No prior radiotherapy * No prior pelvic irradiation Surgery: * No prior radical surgery for carcinoma of the prostate

Locations (1)

Memorial Sloan-Kettering Cancer Center

New York, New York, United States

Data from ClinicalTrials.gov

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