RATIONALE: Drugs used in chemotherapy use different way to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of perillyl alcohol in treating patients with metastatic prostate cancer that has not responded to hormone therapy with androgens.
OBJECTIVES: I. Evaluate the clinical effectiveness of oral perillyl alcohol given to patients with androgen independent metastatic prostate cancer. II. Assess the toxicity of this treatment in these patients. OUTLINE: Patients receive oral perillyl alcohol 4 times a day for 4 weeks. Patients continue treatment in the absence of severe toxicity and disease progression. Patients are followed every 3 months for survival after disease progression. PROJECTED ACCRUAL: This study will accrue 20-40 patients in approximately 2 years.
Study Type
INTERVENTIONAL
Purpose
TREATMENT
Leonard C. Ferguson Cancer Center
Freeport, Illinois, United States
Green Bay Oncology, Ltd.
Green Bay, Wisconsin, United States
Mercy Health System
Janesville, Wisconsin, United States
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, United States
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Meriter Hospital
Madison, Wisconsin, United States
University of Wisconsin Comprehensive Cancer Center
Madison, Wisconsin, United States
Sinai Samaritan Medical Center - Milwaukee
Milwaukee, Wisconsin, United States
North Central Oncology Associates, S.C.
Wausau, Wisconsin, United States