Biological Therapy in Stage I, Stage II, or Stage III Surgically Resected Pancreatic Cancer

Disease Characteristics: * Histologically confirmed stage I, II, or III adenocarcinoma of the pancreas Resected with no gross residual disease At least 50% of tumor cells must be CEA positive and stain with at least moderate intensity HLA-A2 positive Patient Characteristics: * Age: 18 and over * Performance status: Karnofsky 70-100% * Life expectancy: Greater than 6 months * Hematopoietic: Absolute neutrophil count at least 1000/mm3 * Hepatic: Bilirubin less than 2.0 mg/dL SGOT and alkaline phosphatase less than 4 times the upper limit of normal No hepatic failure * Renal: Creatinine less than 2.0 mg/dL OR Creatinine clearance greater than 50 mL/min * Cardiovascular: No New York Heart Association class III or IV heart disease * Pulmonary: No concurrent asthma or chronic obstructive pulmonary disease Other: * No other malignancy except nonmelanoma skin cancer or controlled superficial bladder cancer within the past 5 years. * No history of autoimmune diseases such as inflammatory bowel disease, systemic lupus erythematosus, ankylosing spondylitis, scleroderma, rheumatoid arthritis, or multiple sclerosis * No active acute or chronic infection such as urinary tract infection, HIV, or viral hepatitis * No active infectious enteritis or eosinophilic enteritis Not pregnant or nursing Fertile patients must use effective contraception Prior Therapy: * Biologic therapy: At least 4 weeks since immunotherapy. No other concurrent immunotherapy * Chemotherapy: At least 4 weeks since chemotherapy and recovered. No concurrent chemotherapy * Endocrine therapy: No concurrent corticosteroid or immunosuppressive therapy. At least 6 weeks since steroid therapy * Radiotherapy: At least 4 weeks since radiotherapy and recovered * Surgery: Recovered from prior surgery