Vaccine Therapy in Treating Patients With Metastatic Breast Cancer

* Inclusion Criteria * Patients with a histologically confirmed diagnosis of metastatic adenocarcinoma of the breast. Patients may have measurable disease, but it is not required. Patients may have received any number of prior therapies for metastatic disease. Untreated patients are also eligible. * Age ≥ 18 years * Patients must have an ECOG = Performance Status of 0-1 * Patients must have a WBC \> 2000/mm 3 and a platelet count \> 100,000/mm3. * Patients must have adequate renal function documented by a serum creatinine \< 2.0 mg/d1. * Patients must have adequate liver function demonstrated by a serum bilirubin \< 2.0 mg/di, and a SGPT \< 4 times the upper limit of normal. * ≥3 weeks since chemotherapy (\> 6 weeks for nitosoureas or mitomycin C), hormonal therapy or radiation therapy * Immunologic testing must be at least normal as defined by at least normal delayed type hypersensitivity, at least normal CD4: CD8 ratio (\>1), at least normal lymphocyte proliferation testing (to Con A), and at least normal immunoglobulin levels * Patients must not have evidence of altered immune responsiveness or autoimmune syndromes (scleroderma,systemic lupus erythematosus, etc.). Patients must be HIV negative. This treatment may be associated with increased adverse effects for individuals with immune deficiencies, and HIV-associated symptoms preclude accurate assessment of toxicity. * Patients must not have undergone splenectomy. * Patients with active cases or history of extensive skin disorders (such as extensive psoriasis, burns, impetigo, disseminated zoster) are ineligible. * Patients must not have any other serious medical condition which in the opinion of the investigator is incompatible with the protocol. Patients with active infections requiring antibiotics are not eligible until the infection has cleared and the antibiotics have been stopped for at least 3 days. * Patients must be able to avoid close contact with children \< 3 years of age, pregnant women, individuals with eczema or skin conditions and immune suppressed individuals during a period of two weeks after each vaccination. * Patients must have had prior vaccinia (small pox) exposure. * Tumor tissue positive for staining with MAbs DF3 and/or DF3-P or elevated serum CA15-3. Note: This can be done on stored slides. * Patients must not have a history of seizures, encephalitis or multiple sclerosis. * Patients must not be allergic to eggs. * Patients must not be pregnant or breast-feeding due to a possible increased risk with exposure to vaccinia virus of both mother and newborn as well as unknown risks to the fetus. * Signed informed consent. * Exclusion Criteria * Patients must not have evidence of altered immune responsiveness or autoimmune syndromes (scleroderma, systemic lupus erythematosus, etc.). Patients must be HIV negative This treatment may be associated with increased adverse effects for individuals with immune deficiencies, and HIV-associated symptoms preclude accurate assessment of toxicity. * Patients must not have undergone splenectomy * Patients with active cases or history of extensive skin disorders (such as extensive psoriasis, burns, impetigo, disseminated zoster) are ineligible. * Patients must not have any other serious medical condition which in the opinion of the investigator is incompatible with the protocol. Patients with active infections requiring antibiotics are not eligible until the infection has cleared and the antibiotics have been stopped for at least 3 days.