Effect of Estrogen on Mental and Social Functioning in Girls With Turner's Syndrome

National Institute of Neurological Disorders and Stroke (NINDS)260 enrolled

Overview

RATIONALE: Turner's syndrome is a disease in which females are missing all or part of one X chromosome and do not produce estrogen. Giving estrogen is standard treatment for girls who have Turner's syndrome. Estrogen may be effective treatment for mental and social functioning problems experienced by girls with Turner's syndrome. PURPOSE: Clinical trial to study the effectiveness of long term estrogen therapy on mental and social functioning in girls who have Turner's syndrome.

PROTOCOL OUTLINE: Participants are evaluated for cognitive and social function at entry and 4 years following entry. Assessments include the Wechsler Intelligence Scale for Children-Revised, a child behavior checklist, the Children's Self-Concept Scale, and visual-spatial, visual-motor, attention, memory, language, and facial recognition tasks. Patients (and parents) undergo X-chromosome analysis; brain magnetic imaging is optional. Controls are matched using school selection and telephone interviews. A study duration of 12 years is estimated.

Study Type

INTERVENTIONAL

Purpose

TREATMENT

Enrollment

260

Conditions

Turner's Syndrome

Interventions

EstrogenDRUG

Eligibility

Sex: FEMALEMin age: 8 YearsMax age: 12 YearsHealthy volunteers:

Medical Language ↔ Plain English

PROTOCOL ENTRY CRITERIA: * Girls aged 8 and 12 years with Turner's syndrome-compatible karyotype * Age-matched girls without Turner's syndrome entered as controls * Concurrent registration on Thomas Jefferson University growth study required of subjects with Turner's syndrome

Locations (1)

Jefferson Medical College of Thomas Jefferson University

Philadelphia, Pennsylvania, United States

Data from ClinicalTrials.gov

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