Purification of Testis-Stimulating Factor in Precocious Puberty

National Center for Research Resources (NCRR)4 enrolled

Overview

OBJECTIVES: Purify and characterize a testis-stimulating factor in the blood of adult volunteers who had precocious puberty as boys.

PROTOCOL OUTLINE: Subjects are treated for 2 months with depot injections of leuprolide acetate every 4 weeks and testosterone replacement every 2 weeks. Hormone levels are tested every other week. If luteinizing hormone and follicular-stimulating hormone levels are at or below detection on day 56, blood is drawn for a testis-stimulating factor bioassay and subsequent factor purification and characterization. Volunteers are asked to repeat this 2-month procedure no more than 2 times every 12 months.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Precocious Puberty

Interventions

leuprolideDRUG

testosteroneDRUG

Eligibility

Sex: MALEMin age: 18 Years

Medical Language ↔ Plain English

PROTOCOL ENTRY CRITERIA: Adult men diagnosed with precocious puberty (familial testotoxicosis) as boys

Data from ClinicalTrials.gov

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