Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia

National Center for Research Resources (NCRR)35 enrolled

Overview

OBJECTIVES: I. Study the metabolism of pyruvate and related problems in patients with lactic acidemia. II. Define the nature of the metabolic defect.

PROTOCOL OUTLINE: Patients fast for 6 hours. Glucagon IM is administered after the 6 hour fast. Glucose level is measured at 0, 15, 30, 45, 60, and 90 minutes. In children of sufficient size, alanine and lactic acid should also be measured at each or most of these time points. Fasting continues for at least 18 hours. Glucagon IM is administered again at end of fast. Glucose level is measured at time 0, 15, 30, 45, 60, and 90 minutes.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Mitochondrial Myopathy MELAS Syndrome Lactic Acidosis

Eligibility

Sex: ALL

Medical Language ↔ Plain English

PROTOCOL ENTRY CRITERIA: * Diagnostically documented elevation in lactate, pyruvate, and/or alanine levels in lactic acidemia patients

Locations (1)

University of California San Diego Medical Center

San Diego, California, United States

Data from ClinicalTrials.gov

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