Study of Pituitary Size and Function in Familial Dwarfism of Sindh

National Center for Research Resources (NCRR)4 enrolled

Overview

OBJECTIVES: I. Assess pituitary size and anatomic configuration by magnetic resonance imaging (MRI) in 4 affected dwarfs in the province of Sindh, Pakistan. II. Evaluate ultradian growth hormone (GH) secretory patterns in 4 affected dwarfs.

PROTOCOL OUTLINE: Pituitary size and anatomy and growth hormone response are evaluated. All patients undergo MRI of the pituitary fossa on day 1. On day 2, homozygous patients receive a slow infusion of normal saline with blood sampling every 10 minutes.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Growth Hormone Deficiency

Eligibility

Sex: ALLMin age: 10 YearsMax age: 60 Years

Medical Language ↔ Plain English

* Familial Dwarfism of Sindh * Severe short stature but proportionate without dysmorphic features * Normal body size and weight at birth * Bone age is severely delayed * Puberty is somewhat delayed (age 15-16) * Fertility present in at least 3 dwarfs

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.