Genetic Study of Insulin-Like Growth Factor-I Receptor Mutations in Patients With Intrauterine Growth Retardation

National Center for Research Resources (NCRR)75 enrolled

Overview

OBJECTIVES: I. Determine if mutations in the gene encoding the insulin-like growth factor-I receptor lead to relative insulin-like growth factor-I insensitivity and produce intrauterine growth retardation in children.

PROTOCOL OUTLINE: Patients undergo blood draw. Insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) are measured. Patients whose IGF-I and IGFBP-3 levels are average or above are tested for the presence of mutation in the insulin-like growth factor-I receptor.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Intrauterine Growth Retardation

Eligibility

Sex: ALLMin age: 18 MonthsMax age: 18 Years

Medical Language ↔ Plain English

* Intrauterine growth retardation (IUGR), defined as birth weight less than 2 standard deviations below the mean by Usher and McLean Deficient "catch-up" growth (stature less than 5th percentile on growth chart after age 18 months) Normal or elevated circulating concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) IGF-I or IGFBP-3 within or above the 95th percentile confidence interval for age No other clinical explanation for poor prenatal and postnatal growth No IUGR due to maternal toxemia, endocrine disease, gastrointestinal disease, significant heart disease, or chromosomal abnormalities No other condition known to retard growth

Locations (5)

Emory University School of Medicine

Atlanta, Georgia, United States

TERMINATED

James Whitcomb Riley Hospital for Children

Indianapolis, Indiana, United States

ACTIVE_NOT_RECRUITING

Schneider Children's Hospital

New Hyde Park, New York, United States

Data from ClinicalTrials.gov

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