Study of Allogeneic Bone Marrow Transplantation Following Cyclophosphamide and Radiotherapy in Patients With Fanconi's Anemia

Fairview University Medical Center

Overview

OBJECTIVES: I. Determine the effectiveness of moderate dose cyclophosphamide and total lymphoid radiotherapy in terms of improving the survival and reducing the morbidity following allogeneic bone marrow transplantation in patients with Fanconi's aplastic anemia.

PROTOCOL OUTLINE: Patients receive cyclophosphamide IV over 2 hours on day -6 through -3 and total lymphoid radiotherapy on day -1. Patients undergo allogeneic bone marrow transplantation on day 0. Patients are followed for at least 100 days.

Study Type

INTERVENTIONAL

Purpose

TREATMENT

Conditions

Fanconi's Anemia

Interventions

cyclophosphamideDRUG

Allogeneic Bone Marrow TransplantationPROCEDURE

Eligibility

Sex: ALLMin age: 0 YearsMax age: 54 Years

Medical Language ↔ Plain English

* Diagnosis of severe aplastic anemia with the typical phenotype of Fanconi's anemia: Short stature Hypoplastic radii Skin pigmentation Renal anomalies Chromosomal fragility * Family history of Fanconi's anemia * Histocompatible related donor No evidence of excessive in vitro chromosome fragility typical of Fanconi's anemia Normal CBC and bone marrow

Locations (1)

Fairview University Medical Center

Minneapolis, Minnesota, United States

Data from ClinicalTrials.gov

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