Decompression Intervention of Variceal Rebleeding Trial (DIVERT)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)140 enrolled

Overview

The Decompression Intervention of Variceal Rebleeding Trial (DIVERT) is a multi-center prospective randomized clinical trial comparing the radiologic procedure of transjugular intrahepatic portal-systemic shunt (TIPS) with the surgical procedure of distal splenorenal shunt (DSRS) for variceal bleeding in patients with Child's Class A and B cirrhosis. This is recognized nationally and internationally as the study that will answer the question as to which of these is the best treatment for decompression of varices in patients who have failed endoscopic and pharmacologic therapy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Enrollment

140

Conditions

Esophageal and Gastric Varices Liver Cirrhosis

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Variceal bleeding secondary to cirrhosis and portal hypertension * Child's Class A or B cirrhosis of any etiology * Patients who have failed endoscopic therapy (sclerotherapy or banding) of varices; or patients who are not candidates for endoscopic therapy Exclusion Criteria: * Prior shunt procedure * Portal vein thrombosis * Polycystic liver disease * Intractable ascites * Prior organ transplant * Any medical intractable disease

Locations (5)

University of Miami School of Medicine

Miami, Florida, United States

Emory University

Atlanta, Georgia, United States

Cleveland Clinic Foundation

Cleveland, Ohio, United States

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, United States

University of Wisconsin

Madison, Wisconsin, United States