Safety and Effectiveness of the Drug DPC 083 in Combination With Nucleoside Analogue Reverse Transcriptase Inhibitors in HIV-1-Infected Patients Who Are Failing Treatment With Nonnucleoside Reverse Transcriptase Inhibitors

Inclusion Criteria Patients may be eligible for this study if they: * Have HIV infection. * Are at least 18 years old. * Weigh at least 50 kg. * Have documented evidence of virologic failure. * Have screening HIV genotype done while receiving NNRTI treatment, or within 2 weeks after stopping the treatment. * Have a viral load (amount of HIV in the blood) of at least 1,000 copies/ml within 45 days prior to Day 1 of study. * Are willing to use an effective barrier method of birth control during the study. Birth control agents taken by mouth or placed under the skin should not be used as the only method of birth control. If the patient stops taking the study drug, he or she should continue to use birth control for the following 3 months. Exclusion Criteria Patients will not be eligible for this study if they: * Had virologic failure of any treatment containing an HIV protease inhibitor drug. * Had virologic failure of more than 1 treatment containing an NNRTI drug. * Have participated in any study using DPC 083. * Were treated with any experimental NNRTI. * Have cancer that requires systemic therapy. * Have a history of blood clotting problems. * Have attempted suicide or are in danger of hurting themselves. * Used illegal injection drugs within 6 months of study entry. * Do not expect to complete 12 months on the study. * Have not met requirements for HIV genotyping results. * Have any disease other than HIV infection or other medical problems that the researchers think may interfere with the study. * Have difficulty swallowing capsules/tablets. * Have had treatment with immunomodulatory agents such as interferons, interleukins, or thalidomide within 30 days prior to study entry. * Are using or have used systemic drugs, including glucocorticoids, that suppress the immune system, for over 2 weeks. (Low levels of prednisone are allowed.) * Have used carbamazepine, phenytoin, or Hypericum perforatum (St. John's wort) within 30 days of beginning study treatment. * Have had any vaccination within 3 weeks before study screening. * Have received any experimental therapy within 30 days of beginning study treatment. * Are pregnant or breast-feeding. * Abuse alcohol or drugs.