Lead Mobilization & Bone Turnover in Pregnancy/Lactation

National Institute of Environmental Health Sciences (NIEHS)1,000 enrolled

Overview

We are examining the role of maternal bone lead turnover during pregnancy and lactation as a potential source of lead exposure for the fetus and the infant (via breast milk). A cohort, ascertained at entry to care, consists of \>1000 women to be followed through pregnancy. In the postpartum subjects are recruited for a nested case control study to assess the influence of lactation on maternal bone density, maternal blood lead and breast milk lead.

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

Lead Poisoning

Eligibility

Sex: FEMALEMin age: 12 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

1. Positive pregnancy test, age 12-35 and informed consent; 2. Gestation \<28 weeks at entry to prenatal care; 3. No history of serious chronic or metabolic diseases, which could affect maternal growth or bone density; 4. Not corticosteroid user or diagnosed use of illicit drugs; 5. Eligible for lactation study: Ascertainment during or participation in the pregnancy study and a negative pregnancy test.

Data from ClinicalTrials.gov

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