The purpose of this study is to determine the effect of treatment with Trizivir (TZV) plus efavirenz (EFV) or TZV alone on viral load (level of HIV in the blood).
Patients receive TZV plus EFV in the 48-week Induction Phase. Eligible patients, defined as those with plasma HIV-1 RNA under 50 copies/ml, participate in the 48-week Maintenance Phase. Patients are randomized equally to receive either TZV plus EFV or TZV alone. An immunology substudy will be conducted, including approximately the first 100 patients enrolled who agree to participate.
Study Type
INTERVENTIONAL
Purpose
TREATMENT
Enrollment
400
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Phoenix Body Positive
Phoenix, Arizona, United States
Health for Life Clinic
Little Rock, Arkansas, United States
Orange County Ctr for Special Immunology
Fountain Valley, California, United States
Pacific Horizons Med Group
San Francisco, California, United States
Beacon Clinic / Boulder Community Hosp
Boulder, Colorado, United States
Georgetown Univ Med Ctr
Washington D.C., District of Columbia, United States
Dupont Circle Physicians Group
Washington D.C., District of Columbia, United States
Infectious Disease Consultants
Altamonte Springs, Florida, United States
North Broward Hosp District / HIV Clinical Research
Fort Lauderdale, Florida, United States
Univ of Miami / Jackson Memorial Hosp
Miami, Florida, United States
...and 32 more locations