Treating Alcohol Use In Older Adults With Depression

US Department of Veterans Affairs74 enrolled

Overview

The purpose of this study is to test the efficacy combining a treatment for depression with a treatment for alcohol dependence.

This study aims to study 80 patients with comorbid alcohol dependence and a depressive syndrome. After appropriate detoxification, patients are started on either naltrexone 50 mg or placebo. After one week, sertraline is added in an open label fashion. It is hypothesized that those patients receiving combination therapy will last 3 months with follow-up tracking lasting 1 year.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Alcoholism Depression

Interventions

NALTREXONEDRUG

PlaceboDRUG

Eligibility

Sex: ALLMin age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 55 * Current depressive syndrome * Current alcohol dependence * No psychosis * No opioid or cocaine abuse or dependence Exclusion Criteria:

Locations (1)

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Outcomes

Primary Outcomes

Alcohol use'

Time frame: 12 weeks

Data from ClinicalTrials.gov

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