Allogeneic Peripheral Stem Cell Transplantation in Treating Patients With Stage IV Breast Cancer

Phase 2CompletedNCT00020176

National Cancer Institute (NCI)

Overview

RATIONALE: Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy used to kill tumor cells. PURPOSE: Phase II trial to study the effectiveness of allogeneic peripheral stem cell transplantation in treating patients who have stage IV breast cancer.

OBJECTIVES: * Determine the ability of T-cell-depleted allogeneic blood stem cell transplantation after an immunoablative conditioning regimen to induce a state of mixed host/donor chimerism in patients with metastatic breast cancer. * Determine the ability of this treatment regimen to induce an allogeneic graft-versus-tumor response in these patients. * Determine the feasibility of giving other approved therapies to these patients at the first sign of disease progression in order to stabilize or produce a minimal or partial response. OUTLINE: Patients receive chemotherapy comprising fludarabine IV over 30 minutes and cyclophosphamide IV over 1 hour on days 1-4. Patients receive filgrastim (G-CSF) SC daily beginning on day 5 and continuing until blood counts recover. Treatment repeats every 21 days for a maximum of 2 courses. Patients receive a transplantation preparative regimen comprising fludarabine IV over 30 minutes and cyclophosphamide IV over 2 hours on days -6 to -3 (beginning on day 22 of immune-depleting chemotherapy) followed by allogeneic peripheral blood stem cell transplantation IV on day 0. Patients receive G-CSF SC daily beginning on day 0 and continuing until blood counts recover, plus cyclosporine IV over 1-2 hours every 12 hours on days -1 to 14 and then orally until day 40. Patients with persistent malignant disease and less than grade II acute graft-versus-host disease receive donor lymphocytes IV on days 42, 70, and 98. Patients are followed twice weekly until day 100, and then at 6, 9, 12, 18, and 24 months. PROJECTED ACCRUAL: A maximum of 70 patients will be accrued for this study within 24 months.

Study Type

INTERVENTIONAL

Purpose

TREATMENT

Masking

NONE

Conditions

Breast Cancer

Interventions

filgrastimBIOLOGICAL

therapeutic allogeneic lymphocytesBIOLOGICAL

cyclophosphamideDRUG

cyclosporineDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Stage IV breast cancer * Measurable disease * Progressive disease * Increase in disease mass or less than partial response to therapy * At least one prior chemotherapy regimen for metastatic disease and progressed * Must have received prior therapy with a taxane and an anthracycline * Estrogen/progesterone receptor-positive patients must have received and progressed on at least one hormonal agent in adjuvant or metastatic setting * Her2-neu-expressing patients must have received and progressed on trastuzumab (Herceptin®) in adjuvant or metastatic setting * Prior autologous stem cell transplantation allowed if less than complete response or disease progression in adjuvant or metastatic setting * Consenting first-degree relative with at least 5 out of 6 HLA-antigen match (may include mismatch at the D locus) * Hormone receptor status: * Estrogen receptor status known * Progesterone receptor status known PATIENT CHARACTERISTICS: Age: * 18 to 70 Sex: * Male or female Menopausal status: * Not specified Performance status: * Karnofsky 80-100% Life expectancy: * More than 6 months Hematopoietic: * Not specified Hepatic: * Bilirubin ≤ 2 mg/dL * SGOT \< 4 times upper limit of normal * Hepatitis B surface antigen negative * Hepatitis C antibody negative Renal: * Creatinine ≤ 1.5 mg/dL * Creatinine clearance ≥ 50 mL/min Cardiovascular: * Left ventricular ejection fraction \> 45% Pulmonary: * DLCO ≥ 50% of predicted Other: * HIV negative * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: * See Disease Characteristics * Recovered from prior stem cell transplantation Chemotherapy: * See Disease Characteristics Endocrine therapy: * See Disease Characteristics * No concurrent steroids Radiotherapy: * Not specified Surgery: * Not specified

Locations (2)

Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support

Bethesda, Maryland, United States

NCI - Center for Cancer Research

Bethesda, Maryland, United States

Data from ClinicalTrials.gov

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